Does anyone else have this issue?

Occassionally when I hit start to minimize TurtWoW and do something else. I'll click the icon in my taskbar to return to the game but the game won't appear on my screen, instead my mouse cursor disappears and can only be seen when I hover over the taskbar or start menu. When I try to open task manager and close TurtWoW through using the keyboard (because my cursor disappers) the programme cannot be closed. Instead I have to sign out of windows and only then it'll close. Any ideas on what to do when this happens or how to fix it?